Immunogenicity of a Meningococcal B Vaccine during a University Outbreak.

ABSTRACT:

Backround

In December 2013, a multicomponent meningococcal serogroup B (4CMenB) vaccine was used before licensure on the basis of special consideration by the Food and Drug Administration to respond to an outbreak of Neisseria meningitidis B at a U.S. university. Data suggested that vaccination would control the outbreak because isolates expressed antigens that were closely related to the vaccine antigens (factor H-binding protein [fHbp] and neisserial heparin-binding antigen). We quantified the immune responses induced by 4CMenB during the outbreak.

Methods

We conducted a seroprevalence survey among students to assess vaccination status and collect serum specimens to quantify titers of serum bactericidal antibodies (SBA) with an assay that included human complement (hSBA).

SUBMITTER: Basta NE 

PROVIDER: S-EPMC4992664 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature