Development of a symmetric echo planar imaging framework for clinical translation of rapid dynamic hyperpolarized ¹³ C imaging.

ABSTRACT:

Purpose

To develop symmetric echo planar imaging (EPI) and a reference scan framework for hyperpolarized ¹³ C metabolic imaging.

Methods

Symmetric, ramp-sampled EPI with partial Fourier reconstruction was implemented on a 3T scanner. The framework for acquiring a reference scan on the ¹ H channel and applied to ¹³ C data was described and validated in both phantoms and in vivo metabolism of [1-¹³ C]pyruvate.

Results

Ramp-sampled, symmetric EPI provided a substantial increase in the signal-to-noise ratio of the phantom experiments. The reference scan acquired on the ¹ H channel yielded ¹³ C phantom images that varied in mean signal intensity <2%, compared with ¹³ C images reconstructed with a

SUBMITTER: Gordon JW 

PROVIDER: S-EPMC4992668 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature