Spike-Threshold Variability Originated from Separatrix-Crossing in Neuronal Dynamics.

ABSTRACT: The threshold voltage for action potential generation is a key regulator of neuronal signal processing, yet the mechanism of its dynamic variation is still not well described. In this paper, we propose that threshold phenomena can be classified as parameter thresholds and state thresholds. Voltage thresholds which belong to the state threshold are determined by the 'general separatrix' in state space. We demonstrate that the separatrix generally exists in the state space of neuron models. The general form of separatrix was assumed as the function of both states and stimuli and the previously assumed threshold evolving equation versus time is naturally deduced from the separatrix. In terms of neuronal dynamics, the threshold voltage variation, which is affected by different stimuli, is dete

SUBMITTER: Wang L 

PROVIDER: S-EPMC4992847 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature