HIF-1α and rapamycin act as gerosuppressant in multiple myeloma cells upon genotoxic stress.

ABSTRACT: Multiple myeloma (MM) is still an incurable hematological malignancy. Despite recent progress due to new anti-myeloma agents, the pathology is characterized by a high frequency of de novo or acquired resistance. Delineating the mechanisms of MM resistance is essential for therapeutic advances. We previously showed that long-term genotoxic stress induces the establishment of a senescence-associated secretory phenotype, a pro-inflammatory response that favors the emergence of cells with cancer stem-like properties. Here, we studied the short-term response of MM cells following treatment with various DNA damaging agents such as the energetic C-ion irradiation. MM cells are highly resistant to all treatments and do not enter apoptosis after they arrest cycling at the G2 phase. Although the DNA

SUBMITTER: Coudre C 

PROVIDER: S-EPMC4993538 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature