Modulation of long interspersed nuclear element-1 in the mouse hippocampus during maturation.

ABSTRACT:

Background

Retrotransposition of long interspersed nuclear element-1 (L1-RTP) is proposed to contribute to central nervous system (CNS) plasticity by inducing mosaicism of neuronal cells. Clinical studies have identified increased L1 copy numbers in the brains of patients with psychiatric disorders. These observations implicate that L1-RTP is important for neurogenesis and that its deregulation represents a risk factor for mental disorders. However, no supportive evidence is available for understanding the importance of L1-RTP in CNS function.

Findings

To explore the physiological role of L1-RTP in CNS, we examined the L1 copy number during maturation. Interestingly, the L1 copy number increased after birth in the mouse hippocampus, but not the frontal lobe, with maximal cop

SUBMITTER: Ueno M 

PROVIDER: S-EPMC4993569 | biostudies-literature | 2016 Jul-Aug

REPOSITORIES: biostudies-literature