Predicting clinical outcome from reward circuitry function and white matter structure in behaviorally and emotionally dysregulated youth.

ABSTRACT: Behavioral and emotional dysregulation in childhood may be understood as prodromal to adult psychopathology. Additionally, there is a critical need to identify biomarkers reflecting underlying neuropathological processes that predict clinical/behavioral outcomes in youth. We aimed to identify such biomarkers in youth with behavioral and emotional dysregulation in the Longitudinal Assessment of Manic Symptoms (LAMS) study. We examined neuroimaging measures of function and white matter in the whole brain using 80 youth aged 14.0 (s.d.=2.0) from three clinical sites. Linear regression using the LASSO (Least Absolute Shrinkage and Selection Operator) method for variable selection was used to predict severity of future behavioral and emotional dysregulation measured by the Parent General Behavi

SUBMITTER: Bertocci MA 

PROVIDER: S-EPMC4993633 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature