Functional Networks of Highest-Connected Splice Isoforms: From The Chromosome 17 Human Proteome Project.

ABSTRACT: Alternative splicing allows a single gene to produce multiple transcript-level splice isoforms from which the translated proteins may show differences in their expression and function. Identifying the major functional or canonical isoform is important for understanding gene and protein functions. Identification and characterization of splice isoforms is a stated goal of the HUPO Human Proteome Project and of neXtProt. Multiple efforts have catalogued splice isoforms as "dominant", "principal", or "major" isoforms based on expression or evolutionary traits. In contrast, we recently proposed highest connected isoforms (HCIs) as a new class of canonical isoforms that have the strongest interactions in a functional network and revealed their significantly higher (differential) transcript-level

SUBMITTER: Li HD 

PROVIDER: S-EPMC4993635 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature