Second Curettage for Low-Risk Nonmetastatic Gestational Trophoblastic Neoplasia.

ABSTRACT:

Objective

To evaluate the efficacy and safety of second uterine curettage in lieu of chemotherapy for patients with low-risk, nonmetastatic gestational trophoblastic neoplasia (GTN) and to evaluate whether response to second curettage is independent of patient age, World Health Organization (WHO) risk score, registration human chorionic gonadotropin (hCG) level, lesion size, and depth of myometrial invasion measured on ultrasound examination.

Methods

This was a cooperative group multicenter prospective phase II study. Prestudy testing included quantitative hCG level, pelvic ultrasonography, and chest radiography. Patients were categorized according to WHO risk scoring criteria (low risk with a score of 0-6).

Results

Sixty-four women with newly diagnosed low-risk, nonm

SUBMITTER: Osborne RJ 

PROVIDER: S-EPMC4993663 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature