How Does the Sparse Memory "Engram" Neurons Encode the Memory of a Spatial-Temporal Event?

ABSTRACT: Episodic memory in human brain is not a fixed 2-D picture but a highly dynamic movie serial, integrating information at both the temporal and the spatial domains. Recent studies in neuroscience reveal that memory storage and recall are closely related to the activities in discrete memory engram (trace) neurons within the dentate gyrus region of hippocampus and the layer 2/3 of neocortex. More strikingly, optogenetic reactivation of those memory trace neurons is able to trigger the recall of naturally encoded memory. It is still unknown how the discrete memory traces encode and reactivate the memory. Considering a particular memory normally represents a natural event, which consists of information at both the temporal and spatial domains, it is unknown how the discrete trace neurons could r

SUBMITTER: Guan JS 

PROVIDER: S-EPMC4993949 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature