Kremen1 regulates mechanosensory hair cell development in the mammalian cochlea and the zebrafish lateral line.

ABSTRACT: Here we present spatio-temporal localization of Kremen1, a transmembrane receptor, in the mammalian cochlea, and investigate its role in the formation of sensory organs in mammal and fish model organisms. We show that Kremen1 is expressed in prosensory cells during cochlear development and in supporting cells of the adult mouse cochlea. Based on this expression pattern, we investigated whether Kremen1 functions to modulate cell fate decisions in the prosensory domain of the developing cochlea. We used gain and loss-of-function experiments to show that Kremen1 is sufficient to bias cells towards supporting cell fate, and is implicated in suppression of hair cell formation. In addition to our findings in the mouse cochlea, we examined the effects of over expression and loss of Kremen1 in the

SUBMITTER: Mulvaney JF 

PROVIDER: S-EPMC4994024 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature