Evaluation of outbreak response immunization in the control of pertussis using agent-based modeling.

ABSTRACT:

Background

Pertussis control remains a challenge due to recently observed effects of waning immunity to acellular vaccine and suboptimal vaccine coverage. Multiple outbreaks have been reported in different ages worldwide. For certain outbreaks, public health authorities can launch an outbreak response immunization (ORI) campaign to control pertussis spread. We investigated effects of an outbreak response immunization targeting young adolescents in averting pertussis cases.

Methods

We developed an agent-based model for pertussis transmission representing disease mechanism, waning immunity, vaccination schedule and pathogen transmission in a spatially-explicit 500,000-person contact network representing a typical Canadian Public Health district. Parameters were derived from li

SUBMITTER: Doroshenko A 

PROVIDER: S-EPMC4994102 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature