The effects of prenatal metformin on obesogenic diet-induced alterations in maternal and fetal fatty acid metabolism.

ABSTRACT:

Background

Maternal obesity may program the fetus and increase the susceptibility of the offspring to adult diseases. Metformin crosses the placenta and has been associated with decreased inflammation and reversal of fatty liver in obese leptin-deficient mice. We investigated the effects of metformin on maternal and fetal lipid metabolism and hepatic inflammation using a rat model of diet-induced obesity during pregnancy.

Methods

Female Wistar rats (6-7 weeks old) were fed normal or high calorie diets for 5 weeks. After mating with normal-diet fed males, half of the high calorie-fed dams received metformin (300 mg/kg, daily); dams (8 per group) continued diets through gestational day 19. Maternal and fetal livers and fetal brains were analyzed for fatty acids and for fatty a

SUBMITTER: Harris K 

PROVIDER: S-EPMC4994240 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature