Viral proteins expressed in the protozoan parasite Eimeria tenella are detected by the chicken immune system.

ABSTRACT:

Background

Eimeria species are parasitic protozoa that cause coccidiosis, an intestinal disease commonly characterised by malabsorption, diarrhoea and haemorrhage that is particularly important in chickens. Vaccination against chicken coccidiosis is effective using wild-type or attenuated live parasite lines. The development of protocols to express foreign proteins in Eimeria species has opened up the possibility of using Eimeria live vaccines to deliver heterologous antigens and function as multivalent vaccine vectors that could protect chickens against a range of pathogens.

Results

In this study, genetic complementation was used to express immunoprotective virus antigens in Eimeria tenella. Infectious bursal disease virus (IBDV) causes Gumboro, an immunosuppressive disease

SUBMITTER: Marugan-Hernandez V 

PROVIDER: S-EPMC4994267 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature