Nanowires and Electrical Stimulation Synergistically Improve Functions of hiPSC Cardiac Spheroids.

ABSTRACT: The advancement of human induced pluripotent stem-cell-derived cardiomyocyte (hiPSC-CM) technology has shown promising potential to provide a patient-specific, regenerative cell therapy strategy to treat cardiovascular disease. Despite the progress, the unspecific, underdeveloped phenotype of hiPSC-CMs has shown arrhythmogenic risk and limited functional improvements after transplantation. To address this, tissue engineering strategies have utilized both exogenous and endogenous stimuli to accelerate the development of hiPSC-CMs. Exogenous electrical stimulation provides a biomimetic pacemaker-like stimuli that has been shown to advance the electrical properties of tissue engineered cardiac constructs. Recently, we demonstrated that the incorporation of electrically conductive silicon nano

SUBMITTER: Richards DJ 

PROVIDER: S-EPMC4994528 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature