Baseline subject characteristics predictive of compliance with study-mandated prostate biopsy in men at risk of prostate cancer: results from REDUCE.

ABSTRACT:

Background

Study compliance is crucial when the study outcome is determined by an invasive procedure, such as prostate biopsy. To investigate predictors of compliance in study-mandated prostate biopsies, we analyzed demographic, clinical and reported lifestyle data from the REDUCE trial.

Methods

We retrospectively identified 8025 men from REDUCE with at least 2 years of follow-up, and used multivariable logistic regression to test the association between baseline demographic and clinical characteristics and undergoing the study-mandated prostate biopsy at 2 years. We then examined whether missing any of these data was associated with undergoing a biopsy.

Results

In REDUCE, 22% of men did not undergo a 2-year biopsy. On multivariable analysis, the non-North American re

SUBMITTER: Fischer S 

PROVIDER: S-EPMC4994539 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature