Novel oral anticoagulants for the secondary prevention of cerebral ischemia: a network meta-analysis.

ABSTRACT:

Background

Novel oral anticoagulants (NOACs) have shown to be both safe and effective for ischemic stroke prevention in patients with nonvalvular atrial fibrillation (NVAF). We conducted a network meta-analysis (NMA) using published data from secondary prevention subgroups of different phase III randomized clinical trials (RCTs) comparing individual NOACs with warfarin.

Methods

Eligible studies were identified by searching MEDLINE and SCOPUS and the Cochrane Central Register of Controlled Trials databases. First, we conducted a pairwise meta-analysis for each pairwise comparison, and then we performed NMA to combine direct and indirect evidence for any given pair of treatments. The comparative effects of all NOACs against warfarin were ranked with the surface under the cumul

SUBMITTER: Katsanos AH 

PROVIDER: S-EPMC4994786 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature