Analysis of Viral Diversity in Relation to the Recency of HIV-1C Infection in Botswana.

ABSTRACT:

Background

Cross-sectional, biomarker methods to determine HIV infection recency present a promising and cost-effective alternative to the repeated testing of uninfected individuals. We evaluate a viral-based assay that uses a measure of pairwise distances (PwD) to identify HIV infection recency, and compare its performance with two serologic incidence assays, BED and LAg. In addition, we assess whether combination BED plus PwD or LAg plus PwD screening can improve predictive accuracy by reducing the likelihood of a false-recent result.

Methods

The data comes from 854 time-points and 42 participants enrolled in a primary HIV-1C infection study in Botswana. Time points after treatment initiation or with evidence of multiplicity of infection were excluded from the final analys

SUBMITTER: Moyo S 

PROVIDER: S-EPMC4994946 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature