Maternal Deprivation Influences Pup Ultrasonic Vocalizations of C57BL/6J Mice.

ABSTRACT: Maternal deprivation (MD) is frequently used as an early life stress model in rodents to investigate behavioral and neurological responses under stressful conditions. However, the effect of MD on the early postnatal development of rodents, which is when multiple neural systems become established, is rarely investigated due to methodological limitations. Ultrasonic vocalizations (USVs) are one of the few responses produced by neonatal rodents that can be quantitatively analyzed, and the quantification of USVs is regarded as a novel approach to investigate possible alterations in the neurobehavioral and emotional development of infant rodents under stress. To investigate the effect of MD on pup mice, we subjected C57BL/6J mice to MD and recorded the USVs of pups on postnatal days 1, 3, 7, 8,

SUBMITTER: Yin X 

PROVIDER: S-EPMC4994965 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature