Increased Intestinal Microbial Diversity Following Fecal Microbiota Transplant for Active Crohn's Disease.

ABSTRACT:

Background

The microbiota in the lumen of patients with Crohn's disease (CD) is characterized by reduced diversity, particularly Firmicutes and Bacteroidetes. It is unknown whether the introduction of the intestinal microbiota from healthy individuals could correct this dysbiosis and reverse mucosal inflammation. We investigated the response to fecal microbial transplantation (FMT) from healthy individuals to subjects with active CD.

Methods

We performed a prospective open-label study (uncontrolled) of FMT from healthy donors to subjects with active CD. A single FMT was performed by colonoscopy. Recipients' microbial diversity, mucosal T-cell phenotypes, and clinical and inflammatory parameters were measured over 12 weeks, and safety over 26 weeks.

Results

Nineteen su

SUBMITTER: Vaughn BP 

PROVIDER: S-EPMC4995064 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature