Mitochondria-targeted antioxidants protect against mechanical ventilation-induced diaphragm weakness.

ABSTRACT:

Background

Mechanical ventilation is a life-saving intervention used to provide adequate pulmonary ventilation in patients suffering from respiratory failure. However, prolonged mechanical ventilation is associated with significant diaphragmatic weakness resulting from both myofiber atrophy and contractile dysfunction. Although several signaling pathways contribute to diaphragm weakness during mechanical ventilation, it is established that oxidative stress is required for diaphragmatic weakness to occur. Therefore, identifying the site(s) of mechanical ventilation- induced reactive oxygen species production in the diaphragm is important.

Objective

These experiments tested the hypothesis that elevated mitochondrial reactive oxygen species emission is required for mechanical v

SUBMITTER: Powers SK 

PROVIDER: S-EPMC4995067 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature