Mechanisms of Working Memory Impairment in Schizophrenia.

ABSTRACT:

Background

The neural correlates of working memory (WM) impairment in schizophrenia remain a key puzzle in understanding the cognitive deficits and dysfunction of dorsolateral prefrontal cortex observed in this disorder. We sought to determine whether patients with schizophrenia exhibit an alteration in the inverted-U relationship between WM load and activation that we recently observed in healthy individuals and whether this could account for WM deficits in this population.

Methods

Medicated (n = 30) and unmedicated (n = 21) patients with schizophrenia and healthy control subjects (n = 45) performed the self-ordered WM task during functional magnetic resonance imaging. We identified regions exhibiting an altered fit to an inverted-U relationship between WM load and activati

SUBMITTER: Van Snellenberg JX 

PROVIDER: S-EPMC4995154 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature