Anticipation-related brain connectivity in bipolar and unipolar depression: a graph theory approach.

ABSTRACT: Bipolar disorder is often misdiagnosed as major depressive disorder, which leads to inadequate treatment. Depressed individuals versus healthy control subjects, show increased expectation of negative outcomes. Due to increased impulsivity and risk for mania, however, depressed individuals with bipolar disorder may differ from those with major depressive disorder in neural mechanisms underlying anticipation processes. Graph theory methods for neuroimaging data analysis allow the identification of connectivity between multiple brain regions without prior model specification, and may help to identify neurobiological markers differentiating these disorders, thereby facilitating development of better therapeutic interventions. This study aimed to compare brain connectivity among regions involve

SUBMITTER: Manelis A 

PROVIDER: S-EPMC4995358 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature