The superficial white matter in temporal lobe epilepsy: a key link between structural and functional network disruptions.

ABSTRACT: Drug-resistant temporal lobe epilepsy is increasingly recognized as a system-level disorder affecting the structure and function of large-scale grey matter networks. While diffusion magnetic resonance imaging studies have demonstrated deep fibre tract alterations, the superficial white matter immediately below the cortex has so far been neglected despite its proximity to neocortical regions and key role in maintaining cortico-cortical connectivity. Using multi-modal 3 T magnetic resonance imaging, we mapped the topography of superficial white matter diffusion alterations in 61 consecutive temporal lobe epilepsy patients relative to 38 healthy controls and studied the relationship to large-scale structural as well as functional networks. Our approach continuously sampled mean diffusivity an

SUBMITTER: Liu M 

PROVIDER: S-EPMC4995361 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature