New insights into the heterogeneity of Th17 subsets contributing to HIV-1 persistence during antiretroviral therapy.

ABSTRACT:

Background

Th17 cells are permissive to HIV-1 infection and their depletion from the gut of infected individuals leads to microbial translocation, a major cause for non-AIDS co-morbidities. Most recent evidence supports the contribution of long-lived Th17 cells to HIV persistence during antiretroviral therapy (ART). However, the identity of long-lived Th17 cells remains unknown.

Results

Here, we performed an in-depth transcriptional and functional characterization of four distinct Th17 subsets and investigated their contribution to HIV reservoir persistence during ART. In addition to the previously characterized CCR6(+)CCR4(+) (Th17) and CCR6(+)CXCR3(+) (Th1Th17) subsets, we reveal the existence of two novel CCR6(+) subsets, lacking (double negative, CCR6(+)DN) or co-express

SUBMITTER: Wacleche VS 

PROVIDER: S-EPMC4995622 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature