Multimodal MRI for early diabetic mild cognitive impairment: study protocol of a prospective diagnostic trial.

ABSTRACT:

Background

Type 2 diabetes mellitus (T2DM) is a risk factor for dementia. Mild cognitive impairment (MCI), an intermediary state between normal cognition and dementia, often occurs during the prodromal diabetic stage, making early diagnosis and intervention of MCI very important. Latest neuroimaging techniques revealed some underlying microstructure alterations for diabetic MCI, from certain aspects. But there still lacks an integrated multimodal MRI system to detect early neuroimaging changes in diabetic MCI patients. Thus, we intended to conduct a diagnostic trial using multimodal MRI techniques to detect early diabetic MCI that is determined by the Montreal Cognitive Assessment (MoCA).

Methods

In this study, healthy controls, prodromal diabetes and diabetes subjects (53 s

SUBMITTER: Yu Y 

PROVIDER: S-EPMC4995633 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature