FastProject: a tool for low-dimensional analysis of single-cell RNA-Seq data.

ABSTRACT:

Background

A key challenge in the emerging field of single-cell RNA-Seq is to characterize phenotypic diversity between cells and visualize this information in an informative manner. A common technique when dealing with high-dimensional data is to project the data to 2 or 3 dimensions for visualization. However, there are a variety of methods to achieve this result and once projected, it can be difficult to ascribe biological significance to the observed features. Additionally, when analyzing single-cell data, the relationship between cells can be obscured by technical confounders such as variable gene capture rates.

Results

To aid in the analysis and interpretation of single-cell RNA-Seq data, we have developed FastProject, a software tool which analyzes a gene expression m

SUBMITTER: DeTomaso D 

PROVIDER: S-EPMC4995760 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature