Characterisation of the global transcriptional response to heat shock and the impact of individual genetic variation.

ABSTRACT:

Background

The heat shock transcriptional response is essential to effective cellular function under stress. This is a highly heritable trait but the nature and extent of inter-individual variation in heat shock response remains unresolved.

Methods

We determined global transcription profiles of the heat shock response for a panel of lymphoblastoid cell lines established from 60 founder individuals in the Yoruba HapMap population. We explore the observed differentially expressed gene sets following heat shock, establishing functional annotations, underlying networks and nodal genes involving heat shock factor 1 recruitment. We define a multivariate phenotype for the global transcriptional response to heat shock using partial least squares regression and map this quantitative

SUBMITTER: Humburg P 

PROVIDER: S-EPMC4995779 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature