Inflammatory Cytokines and Antipsychotic-Induced Weight Gain: Review and Clinical Implications.

ABSTRACT: Antipsychotic medications (APs), particularly second-generation APs, are associated with significant weight gain in schizophrenia patients. Recent evidence suggests that the immune system may contribute to antipsychotic-induced weight gain (AIWG) via AP-mediated alterations of cytokine levels. Antipsychotics with a high propensity for weight gain, such as clozapine and olanzapine, influence the expression of immune genes, and induce changes in serum cytokine levels to ultimately down-regulate neuroinflammation. Since inflammatory cytokines are normally involved in anorexigenic responses, reduced inflammation has been independently shown to mediate changes in feeding behaviours and other metabolic parameters, resulting in obesity. Genetic variation in pro-inflammatory cytokines is also asso

SUBMITTER: Fonseka TM 

PROVIDER: S-EPMC4996002 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature