Prostate Cancer Related JAZF1 Gene is Associated with Schizophrenia.

ABSTRACT: Epidemiological studies have shown that there is a reduced risk of prostate cancer among persons diagnosed with schizophrenia (SCZ). However, the mechanism of such relationship is not clear. The reduced incidence of cancer observed in SCZ patients may be related to differences in genetic background. Recently, the JAZF1 gene is found to be associated with prostate cancer and type 2 diabetes. However, no study has focused on the association of JAZF1 with the risk of SCZ. We examined genetic associations of 118 single-nucleotide polymorphisms (SNPs) within the JAZF1 gene with SCZ using one European American (EA) sample of 1,149 cases and 1,347 controls. Logistic regression analysis of SCZ as a binary trait was performed using PLINK software. The most significant association with SCZ was obser

SUBMITTER: Wang KS 

PROVIDER: S-EPMC4996122 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature