Using the Generalized Index of Dissimilarity to Detect Gene-Gene Interactions in Multi-Class Phenotypes.

ABSTRACT: To find genetic association between complex diseases and phenotypic traits, one important procedure is conducting a joint analysis. Multifactor dimensionality reduction (MDR) is an efficient method of examining the interactions between genes in genetic association studies. It commonly assumes a dichotomous classification of the binary phenotypes. Its usual approach to determining the genomic association is to construct a confusion matrix to estimate a classification error, where a binary risk status is determined and assigned to each genotypic multifactor class. While multi-class phenotypes are commonly observed, the current MDR approach does not handle these phenotypes appropriately because the thresholds for the risk statuses may not be clear. In this study, we suggest a new method for e

SUBMITTER: Yee J 

PROVIDER: S-EPMC4996517 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature