Distinct T cell signatures define subsets of patients with multiple sclerosis.

ABSTRACT:

Objective

We investigated T cell responses to myelin proteins in the blood of healthy controls and 2 groups of patients with relapsing-remitting multiple sclerosis (RRMS) who exhibited lesions either predominantly in the brain or predominantly in the spinal cord in order to assess whether distinct neuroinflammatory patterns were associated with different myelin protein-specific T cell effector function profiles and whether these profiles differed from healthy controls.

Methods

Peripheral blood mononuclear cells were obtained from patients with brain-predominant RRMS, patients with spinal cord-predominant RRMS, and age-matched healthy controls and analyzed by enzyme-linked immunosorbent spot assays to quantify interferon gamma-secreting (Th1) and interleukin 17-secreting (Th1

SUBMITTER: Johnson MC 

PROVIDER: S-EPMC4996538 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature