Corpus luteum as a novel target of weight changes that contribute to impaired female reproductive physiology and function.

ABSTRACT:

Unlabelled

Obesity and malnutrition are associated with decreased fecundity in women. Impaired reproductive capacity in obese women is often attributed to anovulation. However, obese women with ovulatory cycles also have reduced fertility, but the etiology of their impaired reproduction is only partially understood. Accumulating evidence suggests that obesity directly impairs oocyte and embryo quality as well as endometrial receptivity. In obese women, urinary progesterone metabolite excretion is decreased, but in excess of what can be explained by suppressed gonadotropin secretion, suggesting that apart from its central effect obesity may directly affect progesterone (P4) production. These observations have led to the novel hypothesis that obesity directly affects corpus luteum (C

SUBMITTER: Kuokkanen S 

PROVIDER: S-EPMC4996623 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature