Ontology highlight
ABSTRACT:
SUBMITTER: Bitto A
PROVIDER: S-EPMC4996648 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
eLife 20160823
The FDA approved drug rapamycin increases lifespan in rodents and delays age-related dysfunction in rodents and humans. Nevertheless, important questions remain regarding the optimal dose, duration, and mechanisms of action in the context of healthy aging. Here we show that 3 months of rapamycin treatment is sufficient to increase life expectancy by up to 60% and improve measures of healthspan in middle-aged mice. This transient treatment is also associated with a remodeling of the microbiome, i ...[more]