Mechanisms linking electrical alternans and clinical ventricular arrhythmia in human heart failure.

ABSTRACT:

Background

Mechanisms of ventricular tachycardia (VT) and ventricular fibrillation (VF) in patients with heart failure (HF) are undefined.

Objective

The purpose of this study was to elucidate VT/VF mechanisms in HF by using a computational-clinical approach.

Methods

In 53 patients with HF and 18 control patients, we established the relationship between low-amplitude action potential voltage alternans (APV-ALT) during ventricular pacing at near-resting heart rates and VT/VF on long-term follow-up. Mechanisms underlying the transition of APV-ALT to VT/VF, which cannot be ascertained in patients, were dissected with multiscale human ventricular models based on human electrophysiological and magnetic resonance imaging data (control and HF).

Results

For patients wit

SUBMITTER: Bayer JD 

PROVIDER: S-EPMC4996715 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature