Absent MicroRNAs in Different Tissues of Patients with Acquired Cardiomyopathy.

ABSTRACT: MicroRNAs (miRNAs) can be found in a wide range of tissues and body fluids, and their specific signatures can be used to determine diseases or predict clinical courses. The miRNA profiles in biological samples (tissue, serum, peripheral blood mononuclear cells or other body fluids) differ significantly even in the same patient and therefore have their own specificity for the presented condition. Complex profiles of deregulated miRNAs are of high interest, whereas the importance of non-expressed miRNAs was ignored. Since miRNAs regulate gene expression rather negatively, absent miRNAs could indicate genes with unaltered expression that therefore are normally expressed in specific compartments or under specific disease situations. For the first time, non-detectable miRNAs in different tissue

SUBMITTER: Siegismund CS 

PROVIDER: S-EPMC4996855 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature