Comparative Gene Expression Analysis of Mouse and Human Cardiac Maturation.

ABSTRACT: Understanding how human cardiomyocytes mature is crucial to realizing stem cell-based heart regeneration, modeling adult heart diseases, and facilitating drug discovery. However, it is not feasible to analyze human samples for maturation due to inaccessibility to samples while cardiomyocytes mature during fetal development and childhood, as well as difficulty in avoiding variations among individuals. Using model animals such as mice can be a useful strategy; nonetheless, it is not well-understood whether and to what degree gene expression profiles during maturation are shared between humans and mice. Therefore, we performed a comparative gene expression analysis of mice and human samples. First, we examined two distinct mice microarray platforms for shared gene expression profiles, aiming

SUBMITTER: Uosaki H 

PROVIDER: S-EPMC4996857 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature