Hyperglycemia induced by pasireotide in patients with Cushing's disease or acromegaly.

ABSTRACT:

Purpose

Cushing's disease (CD) and acromegaly are characterized by excessive hormone secretion resulting in comorbidities such as impaired glucose metabolism, diabetes and hypertension. Pasireotide is a new-generation, multireceptor-targeted somatostatin receptor ligand approved for CD (subcutaneous [SC] injection formulation) and acromegaly (long-acting release [LAR] formulation). In clinical studies of pasireotide, hyperglycemia-related adverse events (AEs) were frequently observed. This review highlights differences in reported rates of hyperglycemia in pasireotide trials and discusses risk factors for and management of pasireotide-associated hyperglycemia.

Methods

Clinical trials evaluating pasireotide in patients with CD or acromegaly were reviewed.

Results

The f

SUBMITTER: Silverstein JM 

PROVIDER: S-EPMC4996868 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature