Targeting Negative Surface Charges of Cancer Cells by Multifunctional Nanoprobes.

ABSTRACT: A set of electrostatically charged, fluorescent, and superparamagnetic nanoprobes was developed for targeting cancer cells without using any molecular biomarkers. The surface electrostatic properties of the established cancer cell lines and primary normal cells were characterized by using these nanoprobes with various electrostatic signs and amplitudes. All twenty two randomly selected cancer cell lines of different organs, but not normal control cells, bound specifically to the positively charged nanoprobes. The relative surface charges of cancer cells could be quantified by the percentage of cells captured magnetically. The activities of glucose metabolism had a profound impact on the surface charge level of cancer cells. The data indicate that an elevated glycolysis in the cancer cells

SUBMITTER: Chen B 

PROVIDER: S-EPMC4997244 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature