Energy metabolism in intestinal epithelial cells during maturation along the crypt-villus axis.

ABSTRACT: Intestinal epithelial cells continuously migrate and mature along crypt-villus axis (CVA), while the changes in energy metabolism during maturation are unclear in neonates. The present study was conducted to test the hypothesis that the energy metabolism in intestinal epithelial cells would be changed during maturation along CVA in neonates. Eight 21-day-old suckling piglets were used. Intestinal epithelial cells were isolated sequentially along CVA, and proteomics was used to analyze the changes in proteins expression in epithelial cells along CVA. The identified differentially expressed proteins were mainly involved in cellular process, metabolic process, biological regulation, pigmentation, multicellular organizational process and so on. The energy metabolism in intestinal epithelial ce

SUBMITTER: Yang H 

PROVIDER: S-EPMC4997266 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature