Biomarkers of browning of white adipose tissue and their regulation during exercise- and diet-induced weight loss.

ABSTRACT:

Background

A hypothesis exists whereby an exercise- or dietary-induced negative energy balance reduces human subcutaneous white adipose tissue (scWAT) mass through the formation of brown-like adipocyte (brite) cells. However, the validity of biomarkers of brite formation has not been robustly evaluated in humans, and clinical data that link brite formation and weight loss are sparse.

Objectives

We used rosiglitazone and primary adipocytes to stringently evaluate a set of biomarkers for brite formation and determined whether the expression of biomarker genes in scWAT could explain the change in body composition in response to exercise training combined with calorie restriction in obese and overweight women (n = 79).

Design

Gene expression was derived from exon DNA micr

SUBMITTER: Nakhuda A 

PROVIDER: S-EPMC4997298 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature