Renal sympathetic denervation in therapy resistant hypertension - pathophysiological aspects and predictors for treatment success.

ABSTRACT: Many forms of human hypertension are associated with an increased systemic sympathetic activity. Especially the renal sympathetic nervous system has been found to play a prominent role in this context. Therefore, catheter-interventional renal sympathetic denervation (RDN) has been established as a treatment for patients suffering from therapy resistant hypertension in the past decade. The initial enthusiasm for this treatment was markedly dampened by the results of the Symplicity-HTN-3 trial, although the transferability of the results into clinical practice to date appears to be questionable. In contrast to the extensive use of RDN in treating hypertensive patients within or without clinical trial settings over the past years, its effects on the complex pathophysiological mechanisms under

SUBMITTER: Fengler K 

PROVIDER: S-EPMC4997524 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature