Menopausal hormone therapy and breast cancer: what is the true size of the increased risk?

ABSTRACT:

Background

Menopausal hormone therapy (MHT) increases breast cancer risk; however, most cohort studies omit MHT use after enrolment and many infer menopausal age.

Methods

We used information from serial questionnaires from the UK Generations Study cohort to estimate hazard ratios (HRs) for breast cancer among post-menopausal women with known menopausal age, and examined biases induced when not updating data on MHT use and including women with inferred menopausal age.

Results

Among women recruited in 2003-2009, at 6 years of follow-up, 58 148 had reached menopause and 96% had completed a follow-up questionnaire. Among 39 183 women with known menopausal age, 775 developed breast cancer, and the HR in relation to current oestrogen plus progestogen MHT use (based on 52 cu

SUBMITTER: Jones ME 

PROVIDER: S-EPMC4997554 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature