Measles Virus Hemagglutinin Protein Epitopes: The Basis of Antigenic Stability.

ABSTRACT: Globally eliminating measles using available vaccines is biologically feasible because the measles virus (MV) hemagglutinin (H) protein is antigenically stable. The H protein is responsible for receptor binding, and is the main target of neutralizing antibodies. The immunodominant epitope, known as the hemagglutinating and noose epitope, is located near the receptor-binding site (RBS). The RBS also contains an immunodominant epitope. Loss of receptor binding correlates with an escape from the neutralization by antibodies that target the epitope at RBS. Another neutralizing epitope is located near RBS and is shielded by an N-linked sugar in certain genotype strains. However, human sera from vaccinees and measles patients neutralized all MV strains with similar efficiencies, regardless of th

SUBMITTER: Tahara M 

PROVIDER: S-EPMC4997578 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature