A system biology approach to understanding the molecular mechanisms of Gubentongluo decoction acting on IgA Nephropathy.

ABSTRACT:

Background

Traditional Chinese medicine (TCM) has been widely used in treating various diseases in eastern Asia for several thousand years, and is becoming increasingly popular in western countries. Gubentongluo (GBTL) decoction, as a classic TCM formula, is commonly applied to treat IgA Nephropathy (IgAN) in China. To date, however, the pharmacological/molecular mechanisms of GBTL have not been fully elucidated.

Method

In the present study, we used a system biological approach to explore these mechanisms acting on IgAN.

Results

First, we found 3876 potential target proteins for GBTL (based on TCMID) and 25 known IgAN associated biomarkers (based on the OMIM or IPA database).16 of the latter biomarkers were direct targets of 6 of the 9 herbs in GBTL, suggesting that t

SUBMITTER: Shen P 

PROVIDER: S-EPMC4997663 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature