Prophylactic Efficacy of Quercetin 3-β-O-d-Glucoside against Ebola Virus Infection.

ABSTRACT: Ebola outbreaks occur on a frequent basis, with the 2014-2015 outbreak in West Africa being the largest one ever recorded. This outbreak has resulted in over 11,000 deaths in four African countries and has received international attention and intervention. Although there are currently no approved therapies or vaccines, many promising candidates are undergoing clinical trials, and several have had success in promoting recovery from Ebola. However, these prophylactics and therapeutics have been designed and tested only against the same species of Ebola virus as the one causing the current outbreak. Future outbreaks involving other species would require reformulation and possibly redevelopment. Therefore, a broad-spectrum alternative is highly desirable. We have found that a flavonoid derivat

SUBMITTER: Qiu X 

PROVIDER: S-EPMC4997876 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature