Non-additive genome-wide association scan reveals a new gene associated with habitual coffee consumption.

ABSTRACT: Coffee is one of the most consumed beverages world-wide and one of the primary sources of caffeine intake. Given its important health and economic impact, the underlying genetics of its consumption has been widely studied. Despite these efforts, much has still to be uncovered. In particular, the use of non-additive genetic models may uncover new information about the genetic variants driving coffee consumption. We have conducted a genome-wide association study in two Italian populations using additive, recessive and dominant models for analysis. This has uncovered a significant association in the PDSS2 gene under the recessive model that has been replicated in an independent cohort from the Netherlands (ERF). The identified gene has been shown to negatively regulate the expression of the c

SUBMITTER: Pirastu N 

PROVIDER: S-EPMC4997959 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature