Current Status of Computer-Aided Drug Design for Type 2 Diabetes

ABSTRACT:

Background

Diabetes is a metabolic disorder that requires multiple therapeutic approaches. The pancreas loses its functionality to properly produce the insulin hormone in patients with diabetes mellitus. In 2012, more than one million people worldwide died as a result of diabetes, which was the eighth leading cause of death.

Objective

Most drugs currently available and approved by the U.S. Food and Drug Administration cannot reach an adequate level of glycemic control in diabetic patients, and have many side effects; thus, new classes of compounds are required. Efforts based on computer-aided drug design (CADD) can mine a large number of databases to produce new and potent hits and minimize the requirement of time and dollars for new discoveries.

Methods

Pharmace

SUBMITTER:  

PROVIDER: S-EPMC4997964 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature