Targeted therapy in cancer.

ABSTRACT:

Purpose

To describe the emergence of targeted therapies that have led to significant breakthroughs in cancer therapy and completed or ongoing clinical trials of novel agents for the treatment of patients with advanced cancer.

Methods

The literature was systematically reviewed, based on clinical experience and the use of technologies that improved our understanding of carcinogenesis.

Results

Genomics and model systems have enabled the validation of novel therapeutic strategies. Tumor molecular profiling has enabled the reclassification of cancer and elucidated some mechanisms of disease progression or resistance to treatment, the heterogeneity between primary and metastatic tumors, and the dynamic changes of tumor molecular profiling over time. Despite the notable tech

SUBMITTER: Tsimberidou AM 

PROVIDER: S-EPMC4998041 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature