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Yeast life-span extension by calorie restriction is independent of NAD fluctuation.

ABSTRACT: Calorie restriction (CR) slows aging in numerous species. In the yeast Saccharomyces cerevisiae, this effect requires Sir2, a conserved NAD+-dependent deacetylase. We report that CR reduces nuclear NAD+ levels in vivo. Moreover, the activity of Sir2 and its human homologue SIRT1 are not affected by physiological alterations in the NAD+:NADH ratio. These data implicate alternate mechanisms of Sir2 regulation by CR.

SUBMITTER: Anderson RM 

PROVIDER: S-EPMC4998187 | biostudies-literature | 2003 Dec

REPOSITORIES: biostudies-literature

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Yeast life-span extension by calorie restriction is independent of NAD fluctuation.

Anderson Rozalyn M RM   Latorre-Esteves Magda M   Neves Ana Rute AR   Lavu Siva S   Medvedik Oliver O   Taylor Christopher C   Howitz Konrad T KT   Santos Helena H   Sinclair David A DA  

Science (New York, N.Y.) 20031106 5653

Calorie restriction (CR) slows aging in numerous species. In the yeast Saccharomyces cerevisiae, this effect requires Sir2, a conserved NAD+-dependent deacetylase. We report that CR reduces nuclear NAD+ levels in vivo. Moreover, the activity of Sir2 and its human homologue SIRT1 are not affected by physiological alterations in the NAD+:NADH ratio. These data implicate alternate mechanisms of Sir2 regulation by CR. ...[more]

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