Association of Major Depressive Episodes With Stroke Risk in a Prospective Study of 0.5 Million Chinese Adults.

ABSTRACT:

Background and purpose

Although the relationship between depression and stroke risk has been investigated, findings in previous reports were conflicting. The aim of this study was to prospectively examine the effect of major depressive episodes (MDE) on stroke incidence and further assess the potential dose-response relationship between number of depression symptoms and subsequent stroke risk in Chinese population.

Methods

A total of 199 294 men and 288 083 women aged 30 to 79 years without a history of stroke, heart disease, and cancer in the China Kadoorie Biobank cohort were followed from 2004 to 2013. A World Health Organization Composite International Diagnostic Interview-Short Form was used to access MDE according to Diagnostic and Statistical Manual of Mental Disorder

SUBMITTER: Sun J 

PROVIDER: S-EPMC4998954 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature